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TrustFinance Global Insights
Feb 03, 2026
2 min read
9

Merck & Co. has projected its 2026 sales and profits to be below Wall Street estimates, primarily due to upcoming patent expirations on key drugs. This cautious long-term outlook has overshadowed a fourth-quarter report that surpassed expectations, driven by its leading cancer drug, Keytruda.
The pharmaceutical giant forecasts 2026 revenue to be in the range of $65.5 billion to $67.0 billion. The high end of this forecast falls short of the average analyst estimate of $67.6 billion. The primary drivers for this conservative guidance are the impending patent losses for its diabetes medication Januvia and muscle relaxant reversal agent Bridion.
The guidance signals significant revenue challenges ahead. Despite Keytruda's strong performance, with fourth-quarter sales reaching $8.37 billion, its own patent protection will expire later this decade. To counter these losses, Merck continues to pursue strategic acquisitions, focusing on deals in the $1 billion to $15 billion range to bolster its drug pipeline.
While Merck's recent quarterly performance was solid, the market is now focused on the company's ability to navigate the upcoming patent cliff. Future growth will heavily depend on the success of its business development strategy and the strength of its acquired assets.
Q: Why is Merck's 2026 forecast lower than analyst expectations?
A: The forecast is lower due to the anticipated loss of revenue from the patent expirations of major drugs, including Januvia.
Q: Which drug was Merck's top performer in the recent quarter?
A: The cancer immunotherapy drug Keytruda was the main driver of growth, with sales of $8.37 billion in the fourth quarter.
Source: Investing.com

TrustFinance Global Insights
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