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TrustFinance Global Insights
Feb 06, 2026
2 min read
11

Clearmind Medicine Inc. (NASDAQ:CMND) stock surged 10.2% in premarket trading after the company announced a development agreement with Polyrizon Ltd. (NASDAQ:PLRZ), whose shares rose 3%. The deal focuses on enhancing the delivery of Clearmind's lead drug candidate, MEAI.
The collaboration will utilize Polyrizon’s advanced intranasal hydrogel technology to create an optimized formulation of MEAI, a non-hallucinogenic compound. This drug is designed for treating addiction-related disorders, weight loss, and other central nervous system conditions.
By partnering, Clearmind aims to leverage the advantages of intranasal delivery, including improved nasal residence time and more targeted application. This delivery route may bypass first-pass metabolism in the liver, potentially allowing for faster absorption and lower effective doses compared to traditional oral administration.
Both companies stated the partnership aims to optimize MEAI's delivery, potentially improving its bioavailability and therapeutic efficacy for patients. It was noted that Polyrizon is a related party to Clearmind under Canadian securities regulations, with Clearmind using exemptions for the transaction.
Q: Why did Clearmind Medicine's stock surge?
A: The stock surged after announcing a development agreement with Polyrizon to enhance the intranasal delivery of its lead drug candidate, MEAI.
Q: What is the main goal of the collaboration?
A: The primary goal is to apply Polyrizon's intranasal hydrogel technology to Clearmind's MEAI compound to improve its effectiveness, absorption, and patient usability.
Source: Investing.com

TrustFinance Global Insights
AI-assisted editorial team by TrustFinance curating reliable financial and economic news from verified global sources.
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